Research

Ambient Ionization Mass Spectrometry

Ambient ionization mass spectrometry (AIMS) is a branch of mass spectrometry in which analyte ionization occurs outside of the mass spectrometer. This enables samples to be analyzed in their natural state with no sample preparation, providing chemical profiles in a matter of seconds. We develop and utilize AIMS techniques for broad applications in the study of the human metabolome, building and optimizing new ion sources for the real-time characterization of small molecules from biological sources.

Whole Body Volatilomics

Whole body volatilomics is an emerging branch of metabolomics in which volatile organic compounds (VOCs) are captured from the human body as a whole. This enables the simultaneous study of VOCs released via skin emissions, exhaled breath and the skin microbiome, providing unparalleled insight into the chemistry of the volatilome. We perform fundamental analytical studies of the whole body volatilome in human cohorts, pioneering the use of this technique as a new tool for human health and disease research.

Human Volatilomics for Health & Disease Research

The human volatilome is influenced by a broad range of factors, including disease, infection, diet, age, sex, genetics, the microbiome and environmental exposure. As such, the study of the volatilome can provide key insight into the health and physiology of a person, enabling the identification of biomarkers for early indication of disease and exposure. We leverage whole body, skin and exhaled breath volatilomics to understand the effects of sickness on the biochemistry of the human body, with the ultimate goal of bridging the gap between laboratory research and clinical practice to develop new non-invasive tools to study and diagnose disease and other health conditions.

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